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Dana Kleimeier

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Research Interests

Research Projects and Scholarships

Deciphering mechanisms of 1-Methyltryptohan induced KYNA increase with mathematical modelling in pigs

Finding most likely pathway with a System of Ordinary Differential Equations, explaining increase of kynurenic acid (KYNA) and tryptophan due to 1-Methyltryptophan administration in pigs, while the intermediate metabolite kynurenine does not change. This project is a cooperation with the Institute of Immunology, University Medicine, Greifswald, Children and Youth clinic, University Rostock and Leibniz Institute for farm animal biology

Modeling Activation of IDO in pigs due to LPS administration

Mathematical modeling is common for data of in vitro cell line experiments or in genetically identical mice, but not in pigs. Regarding the activation of LPS-induced Indolamine-2,3-dioxigenase and its effects on the tryptophan metabolism, we are searching for individual parameters. This project is a cooperation with the Institute of Immunology, University Medicine, Greifswald, Children and Youth clinic, University Rostock and Leibniz Institute for farm animal biology

Modeling staphylococcus aureus infection of dendritic cells

Different staphylococcus aureus strains show different growth behavior in dendritic cells. We want to decipher the mechanisms of dendritic cells allowing varying growth behavior. This project is a cooperation with the Institute of Immunology, University Medicine, Greifswald

Modeling staphylococcus aureus infection

Mathematical Modeling Interactions of Staphylococcus aureus with the adaptive immune systen in different compartments (nose, bones, blood, tissue), in cooperation with the University Medicine Greifswald, Institute of Immunology, Alexander Cole, Burnett School of Biomedical Science, University of central Florida, USA)

Mathematical Modeling of Influenza A virus induced activation of the adaptive immune system in pigs

This project is in line with the project KoInfekt in cooperation with the Friedrich-Loeffler-Institute – Federal Research Institute for Animal Health

Add-on Fellow @ Joachim-Herz-Stiftung | JHS

Add-on Fellowship for Interdisciplinary Life Science

Mentee of Mentoring Program from The University Greifswald | Mentoring

  • Mentor:Jane Heffernan, Director of the Centre for Disease Modelling, York Research Chair (Tier II), Multi-Scale Methods for Evidence-based Health Policy, Faculty of Science - Department of Mathematics & Statistics, York University, Toronto (Canada)
  • Mentor: Alison Hill, Assistant Professor, Biomedical Engineering at the Institute for Computational Medicine, Johns Hopkins University, Baltimore (USA)

    • Conferences and Meetings

    ICSB (Okinawa) | ICSB 2019

    Poster Presentation: From Tryptophan Metabolism to Sepsis Treatment Effects of 1-Methyltryptophan on the kynurenine pathway in pigs

    Workshop on Virus Dynamics (Paris)| 4th Workshop on Virus Dynamics

    Poster Presentation: From Tryptophan Metabolism to Sepsis Treatment - Effects of 1-Methyltryptophan on the kynurenine pathway in pigs

    International Symposium on Systems Biology of Microbial Infection (Jena)| SBMI 2019

    Presentation: From Tryptophan Metabolism to Sepsis Treatment - Effects of 1-Methyltryptophan on the kynurenine pathway in pigs

    Hengstberger Symposium Immonology and Vaccine design (Heidelberg)| Systems Immunology and Vaccine design

    Poster Presentation: A Mathematical Model of Indoleamine 2,3-dioxygenase-mediated Degradation of Tryptophan along the Kynurenine Pathway

    International Symposium on Systems Biology of Microbial Infection (Jena)| SBMI 2017

    Presentation: A Mathematical Model of Indoleamine- 2,3-dioxygenase-mediated Degradation of Tryptophan along the Kynurenine Pathway

    Systems Biology of Human Disease (Heidelberg)| SBHD 2017

    Poster Presentation: A Mathematical Model of Indoleamine-2,3-dioxygenase-mediated Degradation of Tryptophan along the Kynurenine Pathway

    Modeling viral Infections and Immunity (Estes Park, Colorado)| SBHD 2017

    Poster Presentation: A mathematical Model of regaining inflammatory balance

    Workshop on Computational Models in Biology and Medicine (Hannover)| SBHD 2017

    Poster Presentation: A mathematical Model of LPS induced Indoleamine-2,3-dioxygenase activation along the kynurenine pathway in pigs

    Publications

    Matthias Rath, Soenke E.Jenssen, Konrad Schwefel, Stefanie Spiegler, Dana Kleimeier, Christian Sperling, Lars Kaderali, Ute Felbor High-throughput sequencing of the entire genomic regions of CCM1/KRIT1, CCM2 and CCM3/PDCD10 to search for pathogenic deep-intronic splice mutations in cerebral cavernous malformations., European Journal of Medical Genetics, 60(9). 479-484 (2017)
    , 2017; DOI: 10.1016/j.ejmg.2017.06.007