CV
From May 2019 |
Graduate research assistant in the group of Alan Perelson (theoretical biology and biophysics T-6) at the Los Alamos National Laboratory in Los Alamos, New Mexico, U.S.A. |
2018 |
Research stay in the group of Alan Perelson (theoretical biology and biophysics T-6) at the Los Alamos National Laboratory in Los Alamos, New Mexico, U.S.A. |
Since 2015 |
PhD student at the University Medicine Greifswald, Germany |
2013 |
Diploma thesis at the Hans Knoell Institute Jena: "Mathematical Modeling of Infections in XLA Patients under IgG Substitution Therapy" |
2012 - 2013 |
Student research assistant in the Department of Applied Systems Biology at the Hans Knoell Institute Jena, Germany |
2011 - 2012 |
Student research assistant in the Department of Systems Biology and Bioinformatics at the Hans Knoell Institute Jena, Germany |
2007 - 2013 |
Diplom in Bioinformatics at the Friedrich Schiller University Jena |
Ongoing Research Projects
Plus-Strand RNA Virus Replication | SysVirDrug
Plus-strand RNA viruses are a global burden for human health with clinical diversity ranging from common cold (rhinitis) to severe life-threatening diseases (hepatitis C). Nevertheless, these viruses share remarkable similarities in their replication strategy. We use mathematical modeling to study the common steps in the viral life cycle of five plus-strand RNA viruses: Hepatitis C Virus, Dengue Virus, Coxsackievirus B3, Chikungunya Virus, and MERS-Coronavirus.
Dengue Virus Replication and the Innate Immune Response
The Dengue Virus is one of the most prevalent mosquito-borne viruses with globally 390 million infected individuals per year. A primary infection with Dengue Virus causes flu-like illness, occasionally associated with severe complications (e.g. hemorrhagic
fever). In order to compare the Dengue Virus replication in presence and absence of the immune response, we develop detailed mathematical models which couple the DENV replication with and without the activation and antiviral effect of key players of the innate immune response.
Chikungunya Virus Replication
Similar to Dengue, the Chikungunya Virus is transmitted by mosquitos of the Aedes species. The clinical symptoms of a Chikungunya Virus infection are often similar to infections with Dengue or Zika Virus, which often causes misdiagnoses. However, an infection with Chikungunya Virus varies from fever to severe joint pain, eventually turning into a chronic condition. In order to study the highly dynamic initial phase post infection, we develop detailed mathematical models reflecting the intracellular Chikungunya Virus replication.
Publications
Teaching Experience
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